In pregnant women and young infants Influenza could induce a serious disease. The maternal antibodies can pass transplacentally, therefore, it can protect infants during the first months of life. Currently, it is recommended that pregnant women be immunized with the inactivated trivalent influenza vaccine. However, compliance with this recommendation is low. The vaccine is not licensed for infants less than 6 months of age, and antiviral agents are not licensed for children younger than 1 year of age. Thus prevention of influenza by other means is an important goal. A study performed in Bangladesh provides data indicating that maternal vaccination for influenza is safe and efficacious. The vaccine also reducing illness among both mothers and infants, therefore antenatal immunization should be considered as an important strategy for the prevention of influenza.
(N Engl J Med 359:1555, 2008)